Host-based Framework
Infections are best understood through the type of immune dysfunction.
- Barrier disruption
- Chemotherapy, GVHD, mucosal injury, intravascular devices
- Neutropenia
- Severity and duration as determinants of infection risk
- Humoral immunity defects
- Antibody/complement defects, encapsulated bacteria, VPDs
- Cell-mediated immunity defects
- T-cell dysfunction and opportunistic pathogens
Syndrome-based Approach
Common clinical syndromes in hematology practice.
- Febrile neutropenia
- Persistent fever despite broad-spectrum antibiotics
- Skin and soft tissue manifestations in immunocompromised hosts
- Pulmonary infiltrates in immunocompromised hosts
- Unexplained bacteremia / fungemia
Pathogen-oriented Notes
Pathogen-specific considerations in immunocompromised hosts.
- Gram-negative bacteria
- Gram-positive bacteria
- Fungi
- Viruses
- Mycobacteria / Others
Antimicrobial Strategy
Principles of antimicrobial use.
- Empirical therapy
- De-escalation / discontinuation
- Prophylaxis
- Antifungal strategy
Special Topics
Context-specific considerations.
- Transplantation
- CAR-T / bispecific antibodies
- Resistant organisms
- Devices and infection control